General Information

  • ID:  hor002272
  • Uniprot ID:  P19988
  • Protein name:  Leucokinin-6
  • Gene name:  NA
  • Organism:  Rhyparobia maderae (Madeira cockroach) (Leucophaea maderae)
  • Family:  NA
  • Source:  animal
  • Expression:  NA
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Rhyparobia (genus), Oxyhaloinae (subfamily), Blaberidae (family), Blaberoidea (superfamily), Blattodea (order), Dictyoptera (superorder), Polyneoptera (cohort), Neoptera (infraclass), Pterygota (subclass), Dicondylia, Insecta (class), Hexapoda (subphylum), Pancrustacea, Mandibulata, Arthropoda (phylum), Panarthropoda, Ecdysozoa, Protostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  NA
  • GO BP:  GO:0007218 neuropeptide signaling pathway
  • GO CC:  GO:0005576 extracellular region

Sequence Information

  • Sequence:  QSSFHSWG
  • Length:  8(1-8)
  • Propeptide:  QSSFHSWG
  • Signal peptide:  NA
  • Modification:  T1 Pyrrolidone carboxylic acid;T8 Glycine amide
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  Stimulates contractile activity of cockroach protodeum
  • Mechanism:  NA
  • Cross BBB:  NO
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  AF-P01193-F1(AlphaFold_DB_ID)

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    AF-P01193-F1.pdbhor002272_AF2.pdbhor002272_ESM.pdb

Physical Information

Mass: 105999 Formula: C42H54N12O13
Absent amino acids: ACDEIKLMNPRTVY Common amino acids: S
pI: 7.55 Basic residues: 1
Polar residues: 4 Hydrophobic residues: 2
Hydrophobicity: -95 Boman Index: -1415
Half-Life: 0.8 hour Half-Life Yeast: 10 min
Half-Life E.Coli: >10 hour Aliphatic Index 0
Instability Index: 7478.75 Extinction Coefficient cystines: 5500
Absorbance 280nm: 785.71

Literature

  • PubMed ID:  NA
  • Title:  Isolation, primary structure, and synthesis of leucokinins V and VI: myotropic peptides of Leucophaea maderae.